What is CBD?






Cannabidiol (CBD) is one of the naturally occurring cannabinoids found rich in abundance in the Hemp plant. There are at least 113 different cannabinoids isolated from cannabis, with only a few being studied in depth, primarily delta-9-tetrahydrocannabinol (THC) and CBD. 
CBD was isolated from the cannabis plant in 1940 and is now legal in all 50 states of the U.S.  As the major non-psychoactive cannabinoid found in cannabis, CBD has begun to be reviewed by the FDA as an innovative medicine. Since CBD has been shown to both diminish the undesirable “high” effects of THC, while simultaneously expanding the beneficial properties of THC, such as anti-inflammation, the two make a great pair for solutions to relief. When receiving High CBD-Low THC doses, patients obtain the best results. This formula is usually recommended to patients that are starting a Medical Marijuana treatment.

Benefits:
The range of conditions for which CBD has been assessed is diverse. Further studies are under way to explore what role CBD plays in human behavior, such as eating and sleep patterns.
Another possible therapeutic application being investigated is the use of CBD to treat drug addictions, including opioid, cocaine, and psychostimulant addiction, and potentially cannabis and tobacco addiction.
Most recently, CBD has been demonstrated as an effective treatment of epilepsy in several clinical trials, with one pure CBD product (Epidiolex®) currently in Phase III trials. 

How To Use CBD Effectively: 
The evidence from well controlled human experimental research indicates that CBD is not associated with abuse potential and physical dependence effects (e.g. withdrawal and tolerance) of cannabidiol have not been reported. There have also been no toxic effects of CBD on the body according to the relevant findings to date from in vitro and animal studies.
There are multiple different ways to take Cannabidiol into the body, including by inhalation of cannabis smoke or vapor, as an aerosol spray into the cheek, by mouth as a CBD oil and capsules, and others. It may be supplied as CBD oil containing only CBD as the active ingredient (no added THC or terpenes, CBD only) or as a full spectrum containing CBD-dominant and THC containing no more than 0.3% THC in dry weight form (not liquid or extracted form). 
Since, 2015, the FDA and DEA have been working together to streamline the research process regarding CBD’s possible medicinal value and help foster ongoing scientific studies.  If you have the desire to receive more education on CBD products and how they can benefit your conditions, please contact us at ColoWell America, (813) 278-6430. 



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References: 
01: World Health Organization (WHO). Expert Committee on Drug Dependence. Cannabidiol (CBD) Pre-Review Report. Geneva, 6-10 November 2017.
02: Fasinu, P.S., et al., Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents. Pharmacotherapy, 2016. 36(7): p. 781-96.
03: Iffland, K. and F. Grotenhermen, An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and Cannabinoid Research, 2017. 2(1): p. 139-154.
04: Devinsky, O., et al., Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia, 2014. 55(6): p. 791-802.
05: Prud’homme, M., R. Cata, and D. Jutras-Aswad, Cannabidiol as an intervention for addictive behaviors: a systematic review of the evidence. Substance abuse: research and treatment, 2015. 9: p. 33
06: Pisanti, S., et al., Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacol Ther, 2017. 175: p. 133-150
07: Iseger TA, Bossong MG (March 2015). "A systematic review of the antipsychotic properties of cannabidiol in humans". Schizophrenia Research. 162 (1–3): 153–61.
08: Jurkus R, Day HL, Guimarães FS, Lee JL, Bertoglio LJ, Stevenson CW (2016). "Cannabidiol Regulation of Learned Fear: Implications for Treating Anxiety-Related Disorders". Frontiers in Pharmacology. 7: 454
09: Pamplona, Fabricio A.; da Silva, Lorenzo Rolim; Coan, Ana Carolina (12 September 2018). "Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis". Frontiers in Neurology. 9. doi:10.3389/fneur.2018.00759. ISSN 1664-2295. PMC 6143706. PMID 30258398.
10: "FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy". US Food and Drug Administration. 25 June 2018. Retrieved 25 June 2018.
11: Machado Bergamaschi, M., et al., Safety and side effects of cannabidiol, a Cannabis sativa constituent. Current drug safety, 2011. 6(4): p. 237-249.
12: Iffland, K. and F. Grotenhermen, An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and Cannabinoid Research, 2017. 2(1): p. 139-154.
13: United States Department of Justice Drug Enforcement Administration. 1 August 2017]; Available from: https://www.dea.gov/divisions/hq/2015/hq122315.shtml.

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